Syndecan-4 (SDC4) is a transmembrane (type I) heparan sulfate proteoglycan that binds to, and modulates the activity of many extracellular proteins related to cytoskeletal protein binding and fibronectin binding implicated in tumor development (Cai et al., 2020; Godmann et al., 2020). This evidence concerns the gene SDC4 and neoplasm.