Qi-Cai Wu et al. reported that the expressions of SETD2 and METTL14 were elevated in the PASMCs from hypoxia-induced PAH mice, while the lack of SETD2 in PASMCs attenuated the METTL14 expression levels and m6A RNA methylation levels, protected the mice from hypoxia induced pulmonary hypertension (HPH), and significantly reduced the right ventricular systolic pressure (RVSP), right ventricular/left ventricular plus septum [RV/(LV + S)] weight ratio, and pulmonary median width (Zhou et al., 2021b). The gene discussed is METTL14; the disease is pulmonary arterial hypertension.