Firstly, we evaluated CREB3L1 expression pattern and its clinical value in different cancers, and the results suggested that compared with normal tissues, CREB3L1 expression levels were abnormally upregulated in several cancer types, such as BRCA, CHOL, and STAD, whereas was significantly decreased in some cancer types, such as BLCA, COAD, and LUSC. Here, CREB3L1 is linked to cancer.