The results showed that CREB3L1 expression varied from different cancer cell lines, and the expression levels of CREB3L1 were highest in bone, pleura and central nervous system cancer cell lines, while CREB3L1 was expressed lowly in small intestine, oesophagus and salivary gland cancer cell lines compared with other cancer cell lines (Figure 1A). This evidence concerns the gene CREB3L1 and central nervous system cancer.