The Kaplan-Meier curves of PFS indicated that in UCEC (p = 0.003) and PRAD (p = 0.023), patients with low CREB3L1 expression levels had a shorter survival time, while in CESC (p = 0.039), GBM (p = 0.031), KIRP (p = 0.017) and KIRC (p = 0.015), there were better prognoses in patients with low CREB3L1 expression levels (Figure 4C). The gene discussed is CREB3L1; the disease is glioblastoma.