In comparison, CREB3L1 expression levels were abnormally downregulated in tumor samples in 7 cancer types, including bladder urothelial carcinoma (BLCA), colon adenocarcinoma (COAD), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), lung squamous cell carcinoma (LUSC), pheochromocytoma and paraganglioma (PCPG) and rectum adenocarcinoma (READ). The gene discussed is CREB3L1; the disease is rectum adenocarcinoma.