In addition, a recent study conducting scRNA-seq analysis has revealed the critical biomarkers and process of the differentiation of fibroblasts into myofibroblasts in systemic sclerosis, and CREB3L1 may be a critical upstream transcription factor in promoting systemic sclerosis myofibroblast differentiation (Tabib et al., 2021). The gene discussed is CREB3L1; the disease is systemic sclerosis.