Notably, it has been reported that CREB3L1 expression is frequently altered in many cancers, and complex functions and mechanisms of CREB3L1 in cancer development have been clarified in several studies (Feng et al., 2017; Liu et al., 2018; Bissonnette et al., 2021; Morishita et al., 2021). The gene discussed is CREB3L1; the disease is cancer.