Besides, the Kaplan–Meier survival showed that high CREB3L1 expression was significantly correlated with poor OS and DSS in KIRP, MESO, and SKCM, while was related to better OS and DSS in ACC, suggesting the prognostic significance of CREB3L1 in different human cancers. This evidence concerns the gene CREB3L1 and adrenal cortex carcinoma.