In patients with SKCM, uterine corpus endometrial carcinoma (UCEC), esophageal adenocarcinoma (ESCA), CHOL, and head and neck squamous cell carcinoma (HNSC), the high CREB3L1 gene alteration rate was occurred, in which the alteration frequency was higher than 2% (Figure 2A). The gene discussed is CREB3L1; the disease is head and neck squamous cell carcinoma.