KCNJ6 may also play an important role in the generation of infantile spasms associated with cognitive impairment (Cortez et al., 2009; Blichowski et al., 2015; Joshi et al., 2016), as well as in other disorders (Mayfield et al., 2015; Jeremic et al., 2021). This evidence concerns the gene KCNJ6 and Cognitive impairment.