BRCA1 and Hereditary breast and ovarian cancer syndrome: Together with other HR genes—ATM, BARD1, BRIP1, CHEK2, NBS1, PALB2, RAD51C, and RAD51D—and also genes from other biological pathways such as PTEN, STK11, and TP53, BRCA1/2 are usually examined using next-generation sequencing (NGS) multigene panels in hereditary breast and ovarian cancer (HBOC) patients (McAlarnen et al., 2021; Yamamoto and Hirasawa 2021).