This study found a decrease in FKBP5 DNA methylation in BPD phenotype and with different types of psychotherapy (psychodynamic psychotherapy and dialectic behavior therapy) suggesting that psychotherapies, in general, can act as “environmental regulators” (Yehuda et al., 2013) through modification of expression of HPA-axis related genes across several mental disorders. This evidence concerns the gene FKBP5 and psychiatric disorder.