It was found that factors influencing the effective response of PD-1/PD-L1 included the infiltration and localization of early tumor-infiltrating lymphocyte (TIL), activation level of TIL and effects of tumor cell mutation (Kansy et al., 2017; Hellmann et al., 2018; Gao and Chen, 2021). This evidence concerns the gene CD274 and neoplasm.