TP53 and cancer: By using gene expression data, the Asian Cancer Research Group has described four molecular subtypes of GC, including the subtypes of epithelial-mesenchymal transition (EMT), microsatellite instability (MSI), microsatellite stability (MSS)/TP53+ and MSS/TP53-(The Cancer Genome Atlas Research Network, 2014; Cristescu et al., 2015; Oh et al., 2018).