The two segments of FOXM1-PROTAC, in the presence of FOXM1 and E3 ubiquitin ligase, assist the ubiquitination and degradation the FOXM1 protein, thereby inhibiting the proliferation of liver cancer cells, further decreasing the expression of GLUT1 and PD-L1, and reducing glucose metabolism. The gene discussed is SLC2A1; the disease is liver cancer.