ERN1 and Cognitive impairment: All the above results suggested that, once Erbin was knocked out in microglia, its negative regulatory effect on IRE1α/Xbp1s was attenuated, resulting in a relative activation of IRE1α/Xbp1s, thereby activating NLRP3 inflammasome, causing microglia pyroptosis, which released mounts of inflammatory factors, leading to neuronal damage and even cognitive impairment in sepsis mice.