TOPBP1 and neoplasm: Compared with genes that were overexpressed and associated with shorter survival in the TCGA STAD cohort (450 patients, 415 for tumor tissues and 35 for normal tissues; limma-eBayes: log2(RSEM counts + 1) fold changes > 0.5 and P < 0.05), 8 target genes (RPRD1B, MAP4K4, MCM2, TOPBP1, FRMD8, KBTBD2, ADAM10 and CXCR4) were screened from these 2236 genes (Fig. 1A).