The latest paper indicated that p53 prion-like behavior leads to an alteration of the gene expression patterns, such as downregulate the key genes which involved in cycle checkpoints including CDK6, CDK4, CDC45, PCNA, E2F2, RAD51, TIMELESS and upregulate of genes including ERBB2, MAP2K1, EGF. As well as the EMT-associated genes, which contribute to tumor invasion and metastasis can be dysregulated by p53 amyloid formation [23]. This evidence concerns the gene TP53 and neoplasm.