AIRN and Hepatic fibrosis: Further study indicated that Airn inhibits HSC activation indirectly by regulating LSEC differentiation and promoting HC proliferation directly and indirectly by the increased paracrine secretion of Wnt2a and HGF from LSEC, providing the proof that Airn plays a vital role in the orchestration of LSEC/HSC/HC interaction during liver fibrosis and Airn repressed liver fibrosis mainly via inhibiting LSEC capillarization.