According to the Spearman correlation analysis, histological grade (P = 0.015), TNM stages (P = 0.013), lymph node metastasis (P = 0.002), low ER (P = 0.005), low PR (P = 0.027), HER-2 (P = 0.037), and Ki-67 (P < 0.001) were associated with PBK/TOPK protein expression. Here, ESR1 is linked to metastatic malignant neoplasm in the lymph nodes.