ESR1 and metastatic malignant neoplasm in the lymph nodes: In the present study, PBK/TOPK protein expression was positively associated with the risk factors for prognosis, including histological grade (P = 0.015), TNM stages (P = 0.013), lymph node metastasis (P = 0.002), HER-2 (P = 0.037), and Ki-67 (P < 0.001) but negatively associated with the beneficial factors ER (P = 0.005) and PR (P = 0.027).