Univariate Cox regression analysis revealed that tumor size (OS: hazard ratio (HR) = 4.148, P = 0.010; DFS: HR = 3.452, P = 0.007), lymph node metastasis (OS: HR = 3.390, P = 0.012; DFS: HR = 2.351, P = 0.032), HER-2 (OS: HR = 2.016, P = 0.002; DFS: HR = 1.977, P = 0.001), and PBK/TOPK (OS: HR = 4.590, P = 0.003; DFS: HR = 2.890, P = 0.009) were risk factors for both OS and DFS among the included patients. The gene discussed is ERBB2; the disease is metastatic malignant neoplasm in the lymph nodes.