One study from the National Cancer Institute in Bethesda, Maryland, evaluated the reactivity of several IHC markers, calretinin, keratin cocktail (AE1/AE3), and WT-1 immunoreactivity to differentiate malignant mesothelioma from other fibroblastic/myofibroblastic neoplasms. The gene discussed is WT1; the disease is malignant mesothelioma.