We hypothesize that an increase in CD47 expression on periphery TIICs could protect newly recruited leukocytes from macrophage-mediated phagocytosis, while a decrease in CD47 on tumor center TIICs could facilitate the removal of old or anergic leukocytes, allowing antigen-presenting cells to acquire more tumour antigens, ultimately sustaining the antitumor response. The gene discussed is CD47; the disease is neoplasm.