Testa et al. (2018) presented results indicative of the fact that alpha-1 antagonist use may play a role in orthostatic hypotension related syncopes in adults with dementia especially when taken concomitantly with diuretics (adjusted for age and sex RR 1.83, 95% CI 0.85 – 3.96) [53]. This evidence concerns the gene PSMA6 and hypotensive disorder.