Those traits and their associated genes include: neurodegenerative diseases (SPPL2C, NSF, MAPT, KANSL1, CRHR1), neuropsychiatric disorders (KANSL1, FOXO3, CRHR1), neuroticism (NSF, MAPT, KANSL1, FOXO3, CRHR1), intellectual performance (NSF, FOXO3), reaction time (NSF, MAPT, LRRC37A2, FOXO3, ARL17A), cognitive function (MAPT, LRRC37A2, KANSL1, FOXO3, CRHR1, ARL17A), educational attainment (MAPT, FOXO3, CRHR1) and mathematical ability (FOXO3, CRHR1). This evidence concerns the gene CRHR1 and neurodegenerative disease.