IL22RA1 and asthma: Of note, many of the interleukin-10 family cytokines (IL19, IL20, IL24) or their soluble receptors (IL10RB, IL20A, IL22RA1 and IL22RA2) were present in cluster A. Other notable proteins found in cluster A include two members of the IL1 family (IL1B and IL36B), IL11 (a member of the IL6 family which both act on the same receptor [26]), multiple members of the IL17 family (IL17A, IL17B, IL17D, IL17F, and IL25), and IL4 and IL13 which both act on the same receptor to drive severe asthma [27].