CUL4B and lung adenocarcinoma: It has been reported that LINC00519 could be a potential prognostic biomarker and promote the development of lung adenocarcinoma through positively regulated YAP1, which is a pivotal factor in the Hippo pathway38,39 In a recently published report, it was pointed out that THAP7-AS1 can be activated by SP1 transcription, by improving the entry of CUL4B protein into the nucleus to inhibit the expression of miR-22-3p and miR-320a, and it then activated the PI3K/AKT signaling pathway to promote GC progression40.