Regorafenib is an orally available multikinase inhibitor, whose main targets are kinases involved in angiogenesis (VEGFR1–3 and TIE2), oncogenesis (KIT, RET, RAF1, and BRAF), tumor microenvironment (PDGFR and FGFR), and tumor immunity (colony stimulating factor 1 receptor)2,3. The gene discussed is RAF1; the disease is neoplasm.