Interestingly, while the sr sr-liprin-α1-FLAG was able to rescue the defect in MDA-MB-231 tumor cell spreading induced by silencing endogenous liprin-α1, the sr B56γ binding-defective mutant sr-liprin-α1-AA-FLAG was unable to do so (Fig. 4f), indicating that the interaction of B56γ with liprin-α1 mediated by its N-terminal SLiM is important for the integrin-mediated spreading of tumor cells. Here, PPP2R5C is linked to neoplasm.