Interestingly, by employing methylation-sensitive and insensitive anti-PP2A-C Abs, we found that PP2A-C was virtually completely methylated in the highly metastatic MDA-MB-231 breast cancer cell line, and therefore suited for the assembly of B56γ-containing PP2A holoenzymes (Fig. 1h). This evidence concerns the gene PPP2CA and breast carcinoma.