PDPN and neoplasm: As a result, Dptki/kiTgfbr2fl/fl tumours had a significant reduction in the total number of LRRC15+PDPN+ CAFs compared with control Dptwt/wtTgfbr2fl/fl tumours, which indicatedthat LRRC15+ cells depend on TGFβR2 signalling in DPT+ cells for their formation (Fig. 1b,c).