FAP and neoplasm: As previous CAF-depletion strategies have used markers such as α-smooth muscle actin (αSMA, encoded by Acta2) and fibroblast activation protein (FAP, encoded by Fap)14,15, we compared expression levels of Fap and Acta2 to Lrrc15. In KPR tumours, Lrrc15 expression was restricted to fibroblasts, whereas Acta2 and Fap expression was observed in both fibroblasts and pericytes (Extended Data Fig. 3d).