Similar to subcutaneous KPR tumours, development of LRRC15+PDPN+ CAFs in orthotopic pancreatic tumours was significantly impaired in Dptki/kiTgfbr2fl/fl mice compared with control Dptwt/wtTgfbr2fl/fl mice, whereas the total number of PDPN+CD31– fibroblasts remained unchanged (Fig. 1h–j). This evidence concerns the gene PDPN and pancreatic neoplasm.