Within tumour-bearing tissue, fibroblasts could be assigned to four transcriptional expression phenotypes: an Lrrc15 cluster (cluster 0) that also expressed myofibroblast markers such as Tagln and Spp1; a cluster of proliferating CAFs (cluster 5); a cluster of Cxcl14-expressing CAFs (cluster 2); and a cluster of Pi16high CAFs (cluster 1) that shared expression patterns with universal fibroblasts10 (Fig. 3b). Here, LRRC15 is linked to neoplasm.