To investigate the impact of LRRC15+ CAFs on tumour growth and anti-tumour immunity, a genetic mouse model was generated wherein a diphtheria toxin receptor (DTR)–GFP cassette was knocked into exon 2, downstream of the start codon of Lrrc15 (Lrrc15DTRGFP knock-in mice). The gene discussed is LRRC15; the disease is neoplasm.