HAVCR2 and neoplasm: The observed differences in the TIM-3 expression profile following treatment with muPD1-IL2v in the B16-F10-OVA mouse model and the subcutaneous Panc02-H7-Fluc mouse model might reflect the different immunogenicity of the two types of tumours and the relative difference in avidity of the T cell receptors (TCRs) for tumour antigens50.