Immuno-pharmacodynamic analysis of subcutaneous Panc02-H7-Fluc tumours from syngeneic mice showed a progressive and large expansion of CD8+ T cells within the tumours of animals treated with muPD1-IL2v and a beneficial CD8+ T cell/Treg ratio after two single doses of muPD1-IL2v (Fig. 4a,b). This evidence concerns the gene CD8A and neoplasm.