Depletion of HMG20B was sufficient to trigger a leukemia cell differentiation program similar to that observed seen following treatment of leukemia cells with the LSD1 inhibitor OG86; and also to block granulocytic differentiation of normal murine hematopoietic stem and progenitor cells similar to that seen following Gfi1 depletion. This evidence concerns the gene KDM1A and leukemia.