To confirm the reduced interaction of HMG20B with LSD1 following LSD1 inhibition, we performed HMG20B MS-IP using nuclear-enriched protein lysates from THP1 AML cells exposed to either OG86 250 nM or DMSO for 48 h (Fig. 1B and Table S3) and reciprocal IP-western analysis for both HMG20B and LSD1 (Fig. 1C). The gene discussed is KDM1A; the disease is acute myeloid leukemia.