As this is, to the best of our knowledge, the first study to raise the possibility of VSIG1 involvement in tumor cell plasticity, specifically in EMT and Wnt pathway in a similar fashion to β catenin, further research is needed to establish whether the same transcriptional patterns are used by VSIG1, or the molecular machinery is different, at least in part. The gene discussed is VSIG1; the disease is neoplasm.