Because the gastric-type HCC and hepatoid-type of GC seems to share a common origin, in the endodermal rest of the foregut, as we have already hypothesized18,22,23, it is worth considering whether the presence of VSIG1 cytoplasmic immunostaining in HCC cells is a sign of gastric differentiation, or the reverse, that cytoplasmic pattern of VSIG1 expression in GC cells is a sign of hepatoid differentiation. The gene discussed is VSIG1; the disease is gastric cancer.