CASP2 and metabolic disease: It is reasonable that the significance of caspase-2 apoptotic roles in the interaction between miR-34 and caspase-2 were determined in disease states governed by the imbalance of cell death and survival/proliferation (cancer and neuronal damage); but perhaps, given the type of the disease, may also have an effect on other caspase-2 functional roles such as metabolism since liver disease is also categorized as a metabolic disorder [124] and caspase-2 has been established for its metabolic roles [125].