Moreover, bioinformatic analysis and other biochemical approaches, such as luciferase assay and western blotting, revealed caspase-2 as a direct target of miR-708 for bearing the corresponding putative binding site and that the resulting overexpression of caspase-2 was able to offset the anti-apoptotic function of miR-708 in bladder cancer cells [63]. Here, CASP2 is linked to urinary bladder cancer.