In a cerebral stroke study, down-regulation of miR-1247-3p, one of the regulatory miRNAs targeting caspase-2, resulted in the up-regulation of caspase-2 during ischemia/reperfusion (I/R) injury in stroke, as well as, in N2a cells treated with oxygen-glucose deprivation/reoxygenation (OGD/R), an in vitro model for I/R injury [99]. The gene discussed is CASP2; the disease is stroke disorder.