A significant decrease of miR-96-5p was observed in a high fat diet induced NASH model, while bone marrow mesenchymal stem cells (BM-MSCs) and their derived exosomes (BM-MSCs-Exo) were able to serve as a therapeutic treatment for NASH via up-regulating miR-96-5p, which subsequently inhibited caspase-2 to prevent liver apoptosis, hyperlipidemia and hepatic steatosis [108]. Here, CASP2 is linked to metabolic dysfunction-associated steatohepatitis.