In a recent study of gastrointestinal cancer, miR-1247-3p was shown to directly target caspase-2 by decreasing its levels and the exposure to Hippophae rhamnoides L. polyphenols (HPs60) decreased miR-1247-3p levels and correspondingly promoted caspase-2 expression in HPs60-induced apoptotic colon cancer cells [67]. Here, CASP2 is linked to colonic neoplasm.