PCDH8 and depressive disorder: Its expression in the brain is modulated by a GWAS-confirmed risk variant (rs2806933)52,76; its expression is abnormal in the brains of men with depression but not in women with depression8; and the neuroanatomical distribution of abnormal dorsomedial prefrontal connectivity in men with depression is correlated with regional differences in the expression of PCDH8 in both AHBA and Brainspan (Fig. 4c).