To this end, our analyses prioritized at least six genes implicated in depression by high-powered GWAS52, transcriptional analyses8, and our PLS-R models: in females, TMEM161B-AS1 and KLHDC8B, and in males, PRSS16, MRM2, ZKSCAN8P1, and PCDH8—a known regulator of activity-dependent synaptic reorganization. This evidence concerns the gene KLHDC8B and major depressive disorder.