PAK1 and acute myeloid leukemia: The AML-related genes including NRAS (1p13.2), MCL1 (1q21.2), EVI1 (3q26.2), GATA2 (3q21.3), WT1 (11p13), and PAK1 (11q14.1) were amplified in the eccDNAs of AML evolution compared with normal hematopoietic cells.