C4A deficiency, which is also indicated by low copy numbers of C4T or C4L, and higher proportion of C4B among total C4 (C4B/C4T), would disturb such dynamic equilibrium and skew the immune response towards inflammation and autoimmunity with generation of autoantibodies.25 32. This evidence concerns the gene C4B and hyperinsulinemic hypoglycemia, familial, 4.