As the mesolimbic pathway is implicated in anxiety and reward processing, alterations in VTA DAergic activity states paralleled with intra-NAc downregulation of D2R expression (Fig. 4), may be attributable to altered PCE-induced ECb signaling, selectively in males (Hernandez and Cheer, 2015; Wenzel and Cheer, 2018). This evidence concerns the gene DRD2 and Anxiety.