The NPS was significantly and negatively associated with MYC target V2 in 14 cancers, fatty acid metabolism and bile acid metabolism in 18 cancers, peroxisome in 14 cancers, DNA repair in 11 cancers, oxidative phosphorylation in 20 cancers, reduced KRAS signaling in 15 cancers, and spermatogenesis in 26 cancers. Here, MYC is linked to cancer.