Aβ-GFP overexpression decreased the expression of p-ERK (47%, P < 0.001), p-AKT (46%, P < 0.001), and p-CREB (48%, P = 0.002) in cells infected with scrambled shRNA, and the reduction was not worsened by TRKB-specific shRNA infection (P > 0.05). This evidence concerns the gene CREB1 and infection.