Among them, 7,8-DHF demonstrates the features of a potent TRKB agonist and the effects of preventing Aβ deposition, deficits of hippocampal synapses and memory impairment in 5×FAD (APP K670N, M671L, I716V and V717I mutations along with PS1 M146L and L286V mutations) [51] or Tg2576 (APP K670N and M671L mutations) [52] AD mice. Here, APP is linked to Alzheimer disease.