A comparison with the cancer genome atlas TCGA reveals a downregulation of SIRT1 and MAT2B for several urogenital cancer entities like, Bladder Urothelial Carcinoma, Kidney renal papillary cell carcinoma, Kidney Chromophobe, Pan-kidney cohort (KICH+KIRC+KIRP) (Supplementary Figure 5). This evidence concerns the gene MAT2B and cancer.