In addition to tumor size > 6.5 cm, age ≥ 65 years, histological cirrhosis, diabetes mellitus, chronic HCV infection, hemoglobin ≤ 10 g/dL, and albumin ≤ 3.5 g/dL were found to be related to tumor recurrence after liver resection for T1 HCC (all p < 0.05). This evidence concerns the gene ALB and Cirrhosis.