One of the first studies to analyze the epigenetic underpinnings of Nrf2 has been found that the first 5 CpG sites of Nrf2 genetic sequence were hypermethylated in 96% of the analyzed prostate tumors compared to normal prostate tissues, suggesting the importance of methylation in the expression of Nrf2 [44]. This evidence concerns the gene NFE2L2 and prostate neoplasm.