On MRI, patients with OPDM secondary to NOTCH2NLC gene mutation (a common causative genetic mutation in NIID) may show DWI hyperintensity bands along the corticomedullary junction and the MCP sign [68], whereas OPDM secondary to LRP12 gene mutation did not show any abnormal signal intensities or atrophic changes in the case presented by Ishiura et al. [93] as well as 32 case series by Kumutpongpanich et al. [104]. Here, LRP12 is linked to oculopharyngodistal myopathy.