T1D pathogenesis involves the three main memory CD4+ and CD8+ T cell subsets, including central memory (CM; CD45RO+ CD45RA− CCR7+ CD28+), transitional memory (TM; CD45RO+CD45RA−CCR7− CD28+), and effector memory (EM; CD45RO+ CD45RA− CCR7−CD28− CD62Llow).18 Here, CD4 is linked to type 1 diabetes mellitus.