Moreover, in the hypoxia and ischemia‐reperfusion conditions induced by septic ARDS, Hif1 plays a protective role in tissue cells by regulating the expression of heme oxygenase 1(Hmox1), and the Hif1a‐Hmox1 axis plays a key role in autophagy induction and inhibition of reactive oxygen species (ROS) production.22 Here, HIF1A is linked to acute respiratory distress syndrome.