EPRS1 and colon adenocarcinoma: To test whether the L1 RNA 3′UTR contains sequences important for the interaction of L1 RNA with the NCAPD3/condensin II and EPRS/GAIT complexes, a HT-29 human colon adenocarcinoma epithelial cell line was transfected with engineered constructs expressing either a full-length L1 (pJM101/L1.3) or a L1 harboring a deletion of sequences within its 3′UTR (pJM101/L1.3 3′UTRΔ) (Supplementary Figure S1).