Strikingly, further in vivo experimental metastatic assays showed that the promotive effect of VAPA‐enriched LOs education on the HCC bone‐metastasis was also prevented by LOs/187‐1 treatment, as indicated by non‐detectable bone metastatic lesions in the LOs/187‐1‐treated mice, which resulted in longer bone‐metastasis‐free survival (Figure 8C). The gene discussed is VAPA; the disease is hepatocellular carcinoma.