Previously, multiple proteins, such as including cytokeratin 18 (CK18) and αV‐integrin, were identified as LOs marker.[6, 14] Co‐immunoprecipitation (co‐IP) assays showed that VAPA could interact with αV‐integrin, but not CK18, in both HCC cells and HCC cells‐derived LOs (Figure 1I; Figure S2A, Supporting Information). Here, VAPA is linked to hepatocellular carcinoma.