Another protein that triggered our attention was CFHR1 (logFC(MPX‐Control) = −0.8 ± 0.3, logFC(COVID‐19‐Control) = 0.4 ± 0.2), an inhibitor of the terminal pathway of the complement cascade, which was downregulated in MPX but was upregulated in COVID‐19, where it is a marker of disease severity (D'Alessandro et al, 2020; Shen et al, 2020; Demichev et al, 2021). The gene discussed is CFHR1; the disease is COVID-19.