MECOM, a member of the transcriptional regulator family, is of particular interest as it can contribute to the tumorigenesis of HCC 26, 27, and displays histone methyltransferase activity in the monomethylation of Lys9 of histone H3 (H3K9me1) in vitro28, 29. The gene discussed is MECOM; the disease is hepatocellular carcinoma.