Even if there are sufficient TAAs and reprogrammed phagocytes induced by the incorporation role of LNT and UA in the tumor microenvironment (TME), one mechanism that might diminish LNT-UA efficiency is the persistence of a large number of antiphagocytic molecules like CD47, which will send a “don't eat me” signal to inhibit phagocytosis and sequentially attenuate the tumor antigen presentation to T cells via binding to the signal regulatory protein alpha (SIRPα) receptor 28. Here, SIRPA is linked to neoplasm.