Our subsequent RNA pulldown/mass spectrometry results revealed that WEE2-AS1 bound to the m6A reader IGF2BP3, a well-known RNA-binding protein belonging to the insulin-like growth factor 2 mRNA-binding protein (IGF2BP) family, to stabilize their target RNA (Figure 3F and Table S4-1), which has been reported to play oncogenic roles in GBM progression 22. This evidence concerns the gene IGF2BP3 and glioblastoma.