RPN2 and glioblastoma: Moreover, ubiquitination of RPN2 was elevated in WEE2-AS1-knockdown GBM cells and decreased in WEE2-AS1-overexpressing GBM cells compared with their corresponding NC groups (Figure 5E), indicating that WEE2-AS1 regulates the stability of RPN2 protein through ubiquitin-proteasome activity.