CUL2 and glioblastoma: Co-IP assays revealed that compared with the NC group, the binding intensity of CUL2 to RPN2 was obviously reduced in WEE2-AS1-overexpressing GBM cells (Figure 5M), while WEE2-AS1-knockdown did not affect CUL2 protein levels (Figure 5N), suggesting that WEE2-AS1 enhances the stability of RPN2 by inhibiting its binding to CUL2.