Interestingly, the highly metastatic HCCLM3 HCC cell line was reported to show high RhoGEF expression (DOCK1, IQGAP1) 34-35, which might activate Rac1 and maintain GTP-bound Rac1 at a high level regardless of ARHGAP24 overexpression. This evidence concerns the gene ARHGAP24 and hepatocellular carcinoma.