Apart from promoting tumor development by forming pre-metastatic niches and angiogenesis 25, 26, MDSCs could also contribute to immunosuppression through the following mechanisms: 1) Inducting other immunosuppressive cells: MDSCs could not only secret IL-10 and transforming growth factor-β (TGF-β) to directly hamper Teffs but also induce the de novo generation of regulatory T cells (Tregs) mediated by IL-10 and IFN-γ in vivo21. Here, TGFB1 is linked to neoplasm.