Preclinical models demonstrated that IL-8 receptor, CXCR1 or CXCR2, -modified CARs remarkably favored T cell migration and persistence in TME, thereby inducing complete cancer regression and immunologic memory in aggressive tumors such as ovarian, glioblastoma, and pancreatic cancer 147. The gene discussed is CXCR2; the disease is pancreatic neoplasm.