The reason for replacing Glu in the pharmacophore to reduce kidney and salivary gland uptake of PSMA-targeting radioligands was because of the report showing the use of monosodium glutamate to reduce uptake of [68Ga]Ga-PSMA-11 in kidneys and salivary glands but not LNCaP tumor xenografts 15. The gene discussed is FOLH1; the disease is neoplasm.