Importantly, Kaplan-Meier survival analysis also reported that RYR2 downregulation was strongly associated with poor survival of ESCC patients (p = 0.003, log-rank test, Figure 2C, left); the 5-year survival rate in the high RYR2 expression group (30.77%) was substantially lower than that in the low RYR2 expression group (69.23%). This evidence concerns the gene RYR2 and esophageal squamous cell carcinoma.