In our integrated ESCC cohort, the top ten mutations in lipid super-pathway included mutations in kinase PIK3CA and PI4KA, intrinsic factor-vitamin B12 receptor CUBN, phosphatase PTEN, Phospholipase PLB1, acetyl-coenzyme A carboxylase ACACA (also known as ACC1), and ACACB (also known as ACC2), acetyl-coenzyme A synthetase ACSS3, fatty acid synthase FASN, phospholipid-transporting ATPase ABCA1, bile salt export pump ABCB11, and inositol polyphosphate 4-phosphatase INPP4B (Figure 5). Here, PI4KA is linked to esophageal squamous cell carcinoma.