These findings further confirmed the significance of pathways related to circadian entrainment, calcium signaling, glycosaminoglycan degradation, insulin secretion, carbohydrate digestion and absorption, oxytocin signaling, and ABC transporters in ESCC and identified pathways related to galactose metabolism and central carbon metabolism in ESCC (Figure S5C). Here, OXT is linked to esophageal squamous cell carcinoma.