Among these imaging probes are fluorescent tumor-targeted probes such as Tumor Paint, penetrating tumor cells by means of chlorotoxin protein 11, folate receptor-targeted fluorophore EC17 12, vascular endothelial growth factor (VEGF)‐targeted fluorescent tracer 13, and activatable Turn-ON probes such as the cathepsins and the MMPs activatable probes, LUM015 14 and AVP‐620 15, respectively. Here, CTSS is linked to neoplasm.