HK2 and neoplasm: 18F-FDG PET/CT imaging and IHC analysis on the tumor xenograft-bearing animals further confirmed the in vivo decreases of HK2 expression, 18F-FDG tumor accumulation and tumor proliferation upon FGFRi treatment only in FGFRi-sensitive tumors; whereas these decreases were not observed in the FGFRi- de novo and acquired resistant tumors.