HK2 and cancer: Considering that c-Myc functioned as a key downstream effector in aberrantly activated FGFR signaling in cancer 21 and that FGF-induced vascular development was dependent on endothelial glycolysis via MYC/HK2 43, we also tested whether HK2 downregulation by FGFRi was c-Myc dependent in this study.