We also knockdown c-Myc, which was the downstream effector of FGFR via MEK-ERK signaling in FGFR aberrant cancer 21, and no obvious HK2 expression change was exhibited in NCI-H1581 and Hep3B cells (Figure S1), indicating the different regulatory mechanisms by FGF/FGFR for HK2 and c-Myc. This evidence concerns the gene MAP2K7 and cancer.