Another study reported decreased absolute T-cell counts, especially CD8+ T cells, instead of B cell or natural killer cells to be associated with severe infection.25 A systematic review and meta-analysis showed that patients who died had lower lymphocyte counts (mean difference, −395.35 μL; 95% CI, −165.64 to −625.07; P < .001).26 We previously showed that lymphocytopenia at the time of hospital admission was an independent predictor for in-hospital mortality. Here, CD8A is linked to lymphopenia.